Patients should be informed that local and systemic reactions are possible and that prompt medical attention should be sought if allergic reactions occur. Inflammation of the pancreas has been reported rarely in adults receiving growth hormone. In clinical trials the most common adverse reactions included swelling (particularly of the hands or feet) muscle pain joint pain numbness and pain in extremities. Injection site reactions (pain numbness redness swelling). Change (rotate) your injection site to help lower your risk for injection site reactions.