While none of the possible side-effects of Deca will ever be desired by any man, fortunately each one can be avoided, and all it takes is easily within your grasp. In-order to combat such issues, the first line of defense will be an aromatase inhibitor (AI) such as Arimidex or Letrozole; an AI will protect against Gynecomastia produced by aromatase or progestin. Further, an AI will also protect against water retention and can even have a positive impact on blood pressure and cholesterol, but your diet will also play a massive role. Many men who hold water due to Deca use often do even with AI use, and in most cases, it's not the steroid's fault; they're simply eating too much, and it's more than likely too many carbohydrates. By controlling your diet and supplementing with an AI, excess water retention won't be a large concern; further, by controlling your diet, eating a blood pressure and cholesterol friendly diet these issues will be protected; assuming your blood pressure and cholesterol levels were healthy to begin with.
Evidence has accumulated over the pst several years which associates androgenic-anabolic steroid (AAS) use with sudden cardiac death, myocardial infarction, altered serum lipoproteins, and cardiac hypertrophy in humans who habitually use these drugs. Even though some experimental data obtained from animals correlate well with the human findings, the adverse cardiovascular effects of AAS use are poorly understood. The evidence presented in this review suggests that there are at least four hypothetical models of AAS-induced adverse cardiovascular effects: 1) an atherogenic model involving the effects of AAS on lipoprotein concentrations; 2) a thrombosis model involving the effects of AAS on clotting factors and platelets; 3) a vasospasm model involving the effects of AAS on the vascular nitric oxide system; and 4) a direct myocardial injury model involving the effects of AAS on individual myocardial cells. Future studies should be directed at determining the exact mechanisms responsible for AAS-induced adverse cardiovascular effects, at determining the relative contribution of each of these models, and at identifying other possible contributing factors such as metabolism of these steroids and the effects of potential metabolites on various target organs.
Even though anabolic steroids do not cause the same high as other drugs, they can lead to addiction. Studies have shown that animals will self-administer steroids when they have the chance, just as they do with other addictive drugs. People may continue to abuse steroids despite physical problems, high costs to buy the drugs, and negative effects on their relationships. These behaviors reflect steroids' addictive potential. Research has further found that some steroid users turn to other drugs, such as opioids, to reduce sleep problems and irritability caused by steroids.