Naturally occurring steroid hormones

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Of course, radon is in the natural outdoor air as well, but it is diluted by all the air that is available. The Environmental Protection Agency (EPA) did a national survey in the United States and determine that the average indoor air concentration ( picocuries of radon per liter of air) is about three times higher than the average outdoor air concentration ( picocuries per liter). The average indoor air concentration is three times less than the recommended limit ( picocuries per liter). Even though, on average, we could expect our house to have about picocuries per liter of radon, the EPA estimates that nearly 1 out of every 15 homes in the United States has elevated radon levels.

But anyone who questions whether NORC-SSPs make economic sense should look to Israel. The catalyst for its model, created by the nonprofit JDC-ESHEL and supported by the Israeli government and the American Jewish Joint Distribution Committee, was simple research. With the elderly population soaring, the AJJDC compared the initial and annual costs of placing a senior in a nursing home with the costs of NORC services. The difference was dramatic: A nursing home spot for one senior required tens of thousands of dollars to build and maintain, while a NORC-SSP-style program — known in Israel as a “supportive community” — could be set up with a per-capita investment in the hundreds. Israel chose the vastly less expensive supportive community model over costly institutional care.

Brasnjevic et al. [33] summarized the evidence showing that single-strand breaks accumulate with age in the brain (though accumulation differed in different regions of the brain) and that single-strand breaks are the most frequent steady-state DNA damages in the brain. As discussed above, these accumulated single-strand breaks would be expected to block transcription of genes. Consistent with this, as reviewed by Hetman et al., [34] 182 genes were identified and shown to have reduced transcription in the brains of individuals older than 72 years, compared to transcription in the brains of those less than 43 years old. When 40 particular proteins were evaluated in a muscle of rats, the majority of the proteins showed significant decreases during aging from 18 months (mature rat) to 30 months (aged rat) of age. [35]

Naturally occurring steroid hormones

naturally occurring steroid hormones

Brasnjevic et al. [33] summarized the evidence showing that single-strand breaks accumulate with age in the brain (though accumulation differed in different regions of the brain) and that single-strand breaks are the most frequent steady-state DNA damages in the brain. As discussed above, these accumulated single-strand breaks would be expected to block transcription of genes. Consistent with this, as reviewed by Hetman et al., [34] 182 genes were identified and shown to have reduced transcription in the brains of individuals older than 72 years, compared to transcription in the brains of those less than 43 years old. When 40 particular proteins were evaluated in a muscle of rats, the majority of the proteins showed significant decreases during aging from 18 months (mature rat) to 30 months (aged rat) of age. [35]

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