During clinical development for the approved indications, 18560 patients were exposed to XARELTO . These included 7111 patients who received XARELTO 15 mg or 20 mg orally once daily for a mean of 19 months (5558 for 12 months and 2512 for 24 months) to reduce the risk of stroke and systemic embolism in nonvalvular atrial fibrillation (ROCKET AF); 6962 patients who received XARELTO 15 mg orally twice daily for three weeks followed by 20 mg orally once daily to treat DVT or PE (EINSTEIN DVT , EINSTEIN PE), 10 mg or 20 mg orally once daily (EINSTEIN Extension, EINSTEIN CHOICE) to reduce the risk of recurrence of DVT and/or PE; and 4487 patients who received XARELTO 10 mg orally once daily for prophylaxis of DVT following hip or knee replacement surgery (RECORD 1-3).
Generally speaking, medicines are designed to make you feel better. But all drugs, whether taken by mouth or injected, come with a risk of side effects, and hundreds of drugs are known to cause mouth (oral) problems. Medicines used to treat cancer , high blood pressure , severe pain, depression , allergies , and even the common cold , can have a negative impact on your dental health. That's why your dentist, not just your doctor, should always know about all the medications you are taking, including over-the-counter products, vitamins, and supplements .