COX-2 inhibitors have been found to increase the risk of atherothrombosis even with short-term use. A 2006 analysis of 138 randomised trials and almost 150 000 participants  showed that selective COX-2 inhibitors are associated with a moderately increased risk of vascular events, mainly due to a twofold increased risk of myocardial infarction , and also that high-dose regimens of some traditional NSAIDs (such as diclofenac and ibuprofen , but not naproxen ) are associated with a similar increase in risk of vascular events.
Experimental research has examined the effects of resveratrol on human cartilage and human articular chondrocytes (cartilage cells). Research specimens used in this study were derived from articular cartilage explants obtained from healthy femoral head cartilage acquired during routine joint replacement surgery for femoral neck fractures. In this study, resveratrol demonstrated convincing anti-apoptotic (preventing cell death), anti-oxidative (neutralising free radical damage) and anti-inflammatory observations were directly linked to the ability of resveratrol to inhibit the signalling pathway of nuclear factor-kB (NFkB). Shakibaei M (2008).
As with other NSAIDs, anaphylactoid reactions may occur in patients without prior exposure to diclofenac sodium topical gel. Diclofenac sodium topical gel should not be given to patients with the aspirin triad. This symptom complex typically occurs in asthmatic patients who experience rhinitis with or without nasal polyps, or who exhibit severe, potentially fatal bronchospasm after taking aspirin or other NSAIDs [see Contraindications, Warnings and Precautions]. Emergency help should be sought in cases where an anaphylactoid reaction occurs.